BIOPSY-28 Fund $11,450 for ResearchHub Proposal on Psilocybin’s Neuroprotective Role in Stroke

TL;DR

Deploy $11,450 worth of $RSC from the Bio treasury to fund the ResearchHub study: “Effects of Psilocybin and Related Compounds on Neuroprotection in Human Stroke” (ResearchHub Proposal). The study explores psychedelics as geroprotective agents and supports the scientific narrative around PsyDAO’s $LSD and $PSILO compounds launching on Pump Science. It also kickstarts strategic collaboration between BIO and ResearchHub.

Motivation

- Scientific Relevance: Advances a novel geroprotective hypothesis: psychedelics may support neural repair in age-associated diseases like stroke. Preclinical data show that psilocybin reduces infarct volume and improves behavioral outcomes in stroke-induced animal models, likely through upregulation of BDNF and neuronal regeneration markers (BMC Neuroscience, 2024). Additional studies support psilocybin’s role in reducing neuroinflammation and enhancing plasticity via 5-HT₂A receptor pathways, mechanisms central to brain recovery (Frontiers in Neurology, 2021). - Protocol Synergy: Reinforces the scientific foundations of $LSD and $PSILO, creating alignment between token experiments and underlying biology. Human neuroimaging studies also show psilocybin-induced neuroplastic changes and reorganization of brain networks, strengthening the translational link from preclinical to clinical relevance (PMC, 2023). - DeSci Ecosystem Expansion: Builds credibility and working relationships within ResearchHub, enabling future IP sourcing, co-funding, and shared R&D infrastructure across BioDAOs.

Strategic Rationale

This proposal marks the beginning of BIO’s collaboration with ResearchHub, creating a pipeline to scout, fund, and incubate aligned research. By supporting this project early, BIO helps derisk novel science and build visibility across the DeSci ecosystem including (in this case) PsyDAO, VitaDAO, and CerebrumDAO.

Scientific Scope and Deliverables

• Focus: Psilocybin’s modulation of neuroprotective pathways in stroke-affected human brain tissue
• Methods: Ex vivo analysis, biomarker tracking, serotonergic target evaluation
• Deliverables: Open-access datasets, written report, and optional AMA or presentation to the BIO community

Budget

• Total Request: $11,450 USD equivalent in $RSC
• Recipient: ResearchHub-managed fund for the approved project
• Structure: One-time treasury contribution; no IP or equity claims by BioDAO

Strategic Impact for BIO

• Positions BIO as a scientific incubator and strategic funder within DeSci
• Aligns with themes championed by PsyDAO, VitaDAO, CerebrumDAO, and Pump Science
• Early co-funding increases visibility into promising science before further commitment
• Enhances dealflow quality through trusted ResearchHub sourcing
• Expands BIO’s exposure to innovative translational research